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Flat White

Healing from the inside out

Gut health, ketogenic diets, insulin resistance, and the weight of the food pyramid

8 March 2025

9:22 AM

8 March 2025

9:22 AM

For six decades, we’ve followed nutritional advice that promised health but delivered disease. As a physician watching the unfolding epidemic of metabolic illness, I refuse to remain silent about what increasingly appears to be the greatest public health misstep of our time.

The conventional wisdom – eat less fat, more grains, count your calories, and exercise more – has failed spectacularly. Despite dutiful adherence to these guidelines, we’ve witnessed obesity rates skyrocket, diabetes become commonplace, and chronic disease overwhelm our healthcare systems. It’s time to acknowledge an uncomfortable truth: the food pyramid that has guided our eating habits may be fundamentally flawed, if not blatant corruption for profit.

At the heart of our modern health crisis lies insulin resistance – a condition where the body requires ever-increasing amounts of insulin to manage blood glucose. This metabolic dysfunction serves as the precursor not only to Type 2 diabetes but contributes to coronary artery disease, hypertension, non-alcoholic fatty liver disease, polycystic ovary syndrome, certain cancers, and even Alzheimer’s disease (sometimes called ‘Type 3 Diabetes’) as well as increasing evidence of effectiveness of low carb diets in mental health disorders.

The relationship between dietary carbohydrates and insulin is direct and measurable. Higher carbohydrate intake triggers higher insulin production. When this pattern persists over time, insulin resistance develops, creating a vicious cycle that drives metabolic deterioration. Yet our dietary guidelines continue to recommend carbohydrate intake levels that exacerbate this condition for millions already struggling with metabolic health.

The diet-heart hypothesis – the notion that dietary fat, particularly saturated fat and cholesterol, drives heart disease – fuelled the original push toward low-fat diets. Yet when subjected to rigorous clinical trials, this hypothesis has repeatedly failed to hold up. Multiple large-scale studies have shown weak or non-existent connections between saturated fat intake and cardiovascular outcomes. Meanwhile, the replacement of natural fats with industrial vegetable oils high in omega-6 fatty acids may have inadvertently introduced another health risk factor.

Far from being merely a trendy weight-loss approach, low-carbohydrate and ketogenic diets now boast substantial clinical evidence for their efficacy. Research demonstrates not only superior weight loss but also improvements in virtually all metabolic markers. Most striking is their impact on Type 2 diabetes: low-carbohydrate interventions have achieved remission rates up to 60 per cent at one year – compared to just 0.1 per cent with standard dietary approaches.

This stark difference highlights a troubling reality: conventional dietary guidelines have never been properly tested in randomised controlled trials for Type 2 diabetes, despite diabetes being one of our most pressing health crises. We’re treating millions with an unproven approach while resisting alternatives with mounting evidence of effectiveness.


Low-carbohydrate approaches vary in their restrictiveness, ranging from very low-carbohydrate ketogenic diets (30g or less daily) to more moderate approaches (50-130g daily). This flexibility allows for individualisation based on specific health conditions and personal preferences. For some conditions – including fatty liver, epilepsy, severe diabetes, and certain autoimmune and neurological disorders – the more restrictive ketogenic approach may offer particular benefits. For others, a more

The potential applications extend well beyond weight management to include metabolic syndrome, fatty liver disease, both types of diabetes, PCOS and infertility, migraines, autoimmune diseases, and various digestive disorders. Each of these conditions involves inflammation and metabolic dysfunction that can respond dramatically to dietary intervention.

Yet despite this growing evidence, institutional resistance to low-carbohydrate approaches remains formidable. This resistance stems from entrenched nutritional dogma, commercial interests in the food industry, and ideological factors including misguided environmental concerns about animal agriculture. The result has been a system where outdated nutritional advice continues to be dispensed despite its apparent contribution to worsening health outcomes.

Critics often dismiss low-carbohydrate diets as ‘fad diets’, yet historical evidence shows that humanity thrived on diverse diets – including many very low in carbohydrates – long before the advent of modern processed foods. The real fad diet may be our current high-carbohydrate, low-fat approach, which has coincided with unprecedented levels of chronic disease.

For patients struggling with obesity, diabetes, or other metabolic conditions, conventional advice to eat less fat and more carbohydrates may be precisely backward. Instead, limiting carbohydrates (particularly refined ones) while embracing natural fats often proves more effective for restoring metabolic health.

The gut microbiome represents another frontier in our understanding of metabolic health. Emerging research suggests that low-carbohydrate diets may favourably alter gut bacteria composition, reducing inflammation and improving metabolic function from the inside out. This ‘healing from the inside out’ approach acknowledges the complex interplay between our diet, gut health, and overall metabolic function.

After decades of watching failing approaches being repeatedly recommended, I believe we’ve reached a tipping point. The evidence supporting carbohydrate restriction for metabolic health has become too substantial to ignore. For clinicians and patients alike, embracing these evidence-based alternatives offers hope where conventional approaches have failed.

As our understanding of nutrition evolves, our dietary guidelines must follow the evidence, not dogma. The growing body of research supporting low-carbohydrate approaches deserves serious consideration by health authorities, practitioners, and patients alike. The health of future generations may depend on our willingness to question established wisdom and embrace more effective nutritional paradigms.

The time has come to relieve ourselves of the weight of the food pyramid and explore approaches that truly heal from the inside out.


Dr Andrew McIntyre – Consultant Gastroenterologist on Queensland’s Sunshine Coast

Kara Thomas – is the Secretary of the Australian Medical Professionals’ Society.

The above is the opinion of the authors and not intended as health advice.

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